• Patch-clamp recording in cerebellar slices. 200-300 micrometers thick cerebellar slices are used to investigate neuronal and synaptic properties. The patch-clamp technique allows recording from a single cell.

• Ca2+ imaging. With this technique cells recorded during an whole-cell patch-clamp experiment are loaded with a fluorescent dye. Flourescence allows to measure intracellular Ca2+ concentration changes using a CCD camera.

• Voltage-Sensitive Dyes (VSD) recordings in cerebellar slices. VSD allows to measure membrane potential variations at a network level.

• Multielectrode recording. With this technique it is possible to record extracellular electrical activity simultaneously from up to 60 electrodes in cerebellar slices. This technique is important to understand the spatial organisation of synaptic plasticity and intrinsic signal processing.

• In vivo recording. Field potential recordings in vivo are used to understand the natural discharge pattern of neurons.

• Mathematical simulation. Membrane properties and intracellular Ca2+ dynamics derived from physiological experiments are represented in a mathematical form, and a realistic simulation of neuronal excitability is reconstructed. Neuronal models allow theoretical investigation of membrane biophysics and of neuronal networks. Multi-compartmental models of Granule and Golgi cell are now available and modeled with high morphological and physiological details.