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Extracellular Matrix Lab, Milano
Research Group

University of Milan
Department of Biomedical Sciences for Health
via Mangiagalli, 31, 20133 Milano

Background and specific aims

The research activity is mainly focused on:

  • extracellular matrix remodeling and collagen turnover in physiological and pathological conditions  (fibrosis, aging, tendon connective tissue homeostasis, tunor invasion, gingival overgrowth)
  • epithelial-to-mesenchymal transition.

Research projects

The main research projects are: 

1) Characterization of extracellular matrix remodeling and collagen turnover mechanisms in human tendons and tenocytes during aging and in pathological conditions, by morphological and molecular methods.

2) Characterization of the effect of extracellular matrix components on pancreatic ductal adenocarcinoma cell phenotype, with particular attention to the expression of epithelial-to-mesenchymal transition markers

Facilities and equipment


cell biology, gene expression analysis, western blot, zimography, immunofluorescence, histological techniques.

Recent pubblications
Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: characterization in a 3D-cell culture model. - N. Gagliano, G. Celesti, L. Tacchini, S. Pluchino, C. Sforza, M. Rasile, V. Valerio, L. Laghi, V. Conte, P. Procacci. - World J Gastroenterol 22: 4466-4483 ( 2016 )
Human palate and tuberosity mucosa as donor sites for ridge augmentation - C. Dellavia, G. Ricci, L. Pettinari, C. Allievi, F. Grizzi, N. Gagliano. - International Journal of Periodontics & Restorative Dentistry 34:179-186 ( 2014 )
New insights in extracellular matrix remodeling and collagen turnover related pathways in cultured human tenocytes after Ciprofloxacin administration - A. Menon, L, Pettinari, C, Martinelli, G. Colombo, N. Portinaro, I. Dalle-Donne, M.C. d’Agostino, N. Gagliano - Muscle, Ligaments and Tendons Journal 3: 122-131 ( 2013 )

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Last update: january 08th 2017 h 15:20
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