The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by the study of three-dimensional structures of macromolecules, using crystallography and cryo- electron microscopy. These methods are integrated by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes understanding the reactivity of flavoenzymes with oxygen (Mattevi), extracellular systems involved in signal transduction and in ECM assembly (Forneris), enzymes of the neurotransmitter metabolism (Binda), membrane proteins (Magnani), and protein complexes involved in chromatin remodeling (Mattevi).
22/07/2020 - New Publication
Francesca Magnani contributed to the the development of a new angiotensin receptor peptide agonist with enhanced stability in serum compared to the parent compound. Moreover, the novel analogue discriminates between the 2 angiotensin receptors that are characterised by opposing biological functions, binding more tightly the Angiotensin type-2 receptor with consequent neurotrophic effect.. Full story published on Chemistry - A European Journal. - Browse the publications of our groups.
03/07/2020 - New Publication
A sinergy between the Binda team and a group at INSERM Toulouse allowed to apply an enzymology combined to cell biology approach to study the role of Monoamine Oxidase A in ROS production in the heart and in cardiac ageing. Full story published on ACS Chem Biol. - Browse the publications of our groups.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)< br>
