Structural Biology @ UniPV
Dept. of Biology and Biotechnology - University of Pavia

List of Publications

2020

• Bruni M, Cecatiello V, Diaz-Basabe A, Lattanzi G, Mileti E, Monzani S, Pirovano L, Rizzelli F, Visintin C, Bonizzi G, Giani M, Lavitrano ML, Faravelli S, Forneris F, Caprioli F, Pelicci PG, Natoli G, Pasqualato S, Mapelli M, Facciotti F.
  Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers
  J Clin Med, 9, pp. 3188. (2020) - Link to Publication


• Oosterheert W, Reis J, Gros P, Mattevi A.
  An Elegant Four-Helical Fold in NOX and STEAP Enzymes Facilitates Electron Transport across Biomembranes-Similar Vehicle, Different Destination
  Acc Chem Res, in press. (2020)


• Iacovino LG, Savino S, Borg AJE, Binda C, Nidetzky B, Mattevi A.
  Crystallographic snapshots of UDP-glucuronic acid 4-epimeraseligand binding, rotation and reduction
  J Biol Chem, in press. (2020)


• Buezo Montero S., Gabrieli P., Montarsi F., Borean A., Capelli S., De Silvestro G., Forneris F., Pombi M., Breda A., Capelli G., Arcà B.
  IgG Antibody Responses to the Aedes albopictus 34k2 Salivary Protein as Novel Candidate Marker of Human Exposure to the Tiger Mosquito
  Front Cell Infect Microbiol, 10, pp. 377. (2020) - Link to Publication


• Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N, Grob NM, Stylos EK, Shaye H, Del Borgo M, Aguilar MI, Magnani F, Syed N, Crook T, Waqif E, Ghazaly E, Cherezov V, Widdop RE, Luchinat C, Michael-Titus AT, Mindt TL, Tzakos AG
  Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity
  Chemistry, in press. (2020)


• Iacovino LG, Manzella N, Resta J, Vanoni MA, Rotilio L, Pisani L, Edmondson DE, Parini A, Mattevi A, Mialet-Perez J, Binda C.
  Rational re-design of Monoamine Oxidase A into a dehydrogenase to probe ROS in cardiac ageing
  ACS Chem Biol, in press. (2020)


• Iacovino LG, Reis J, Mai A, Binda C, Mattevi A.
  Diphenylene iodonium is a non-covalent MAO inhibitor: a biochemical and structural analysis
  ChemMedChem, in press. (2020)


• Ernst S, Rovida S, Mattevi A, Fetzner S, Drees SL.
  Photoinduced monooxygenation involving NAD(P)H-FAD sequential single-electron transfer
  Nat Commun, 11, pp. 2600. (2020)


• Ravasio R, Ceccacci E, Nicosia L, Hosseini A, Rossi PL, Barozzi I, Fornasari L, Zuffo RD, Valente S, Fioravanti R, Mercurio C, Varasi M, Mattevi A, Mai A, Pavesi G, Bonaldi T, Minucci S
  Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation
  Sci Adv, 6, pp. eaax2746. (2020)


• Chiabrando D, Scietti L, Prajica AG, Bertino F, Tolosano E, Magnani F
  Expression and purification of the heme exporter FLVCR1a
  Protein Expr Purif, 172, pp. 105637. (2020)


• Selvanathan A, Nixon CY, Zhu Y, Scietti L, Forneris F, Moreno Uribe LM, Lidral AC Jezewski PA, Mulliken JB, Murray JC, Buckley MF, Cox TC, Roscioli T
  CDH1 Mutation Distribution and Type Suggests Genetic Differences Between the Etiology of Orofacial Clefting and Gastric Cancer
  Genes, 11, pp. 391. (2020)


• Aalbers FS, Furst MJ, Rovida S, Trajkovic M, Gomez-Castellanos JR, Bartsch S, Vogel A, Mattevi A, Fraaije MW
  Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering
  eLife, 9, pp. e54639. (2020)


• Reis J, Massari M, Marchese S, Ceccon M, Aalbers FS, Corana F, Valente S, Mai A, Magnani F, Mattevi A.
  A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action
  Redox Biol, 32, pp. 101466. (2020)


• Fioravanti R, Romanelli A, Mautone N, Di Bello E, Rovere A, Corinti D, Zwergel C, Valente S, Rotili D, Botrugno OA, Dessanti P, Vultaggio S, Vianello P, Cappa A, Binda C, Mattevi A, Minucci S, Mercurio C, Varasi M, Mai A.
  Tranylcypromine-based LSD1 Inhibitors: Structure-Activity Relationship, Antiproliferative Effect in Leukemias and Gene Target Modulation
  ChemMedChem, in press. (2020)


• Knez D, Colettis N, Iacovino LG, Sova M, Pišlar A, Konc J, Lešnik S, Higgs J, Kamecki F, Mangialavori I, Dolšak A, Žakelj S, Trontelj J, Kos J, Binda C, Marder M, Gobec S.
  Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B
  J Med Chem, 63, pp. 1361-1387. (2020)


• Guarino SR*, Canciani A*, Forneris F.
  Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers
  Front Mol Biosci, 6, pp. 156. (2020) - *Equal Contribution




2019

• Nicoll CR, Bailleul G, Fiorentini F, Mascotti ML*, Fraaije MW*, Mattevi A.*
  Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
  Nat Struct Mol Biol, 27, pp. 14-24. (2019) - *Shared Corresponding Authors - News and Views Preview


• Marconcini M, Hernandez L, Iovino G, Houé V, Valerio F, Palatini U, Pischedda E, Crawford JE, White BJ, Lin T, Carballar-Lejarazu R, Ometto L, Forneris F, Failloux AB, Bonizzoni M.
  Polymorphism analyses and protein modelling inform on functional specialization of Piwi clade genes in the arboviral vector Aedes albopictus
  PLoS Negl Trop Dis, 13, pp. e0007919. (2019)


• Millana-Fañanas E, Todesca S, Siccorello A, Masino L, Pompach P, Magnani F, Pastore A*, Mattevi A.*
  On the mechanism of calcium-dependent activation of NADPH oxidase 5 (NOX5)
  FEBS J, in press. (2019) - *Shared Corresponding Authors


• Savino S, Borg AJE, Dennig A, Pfeiffer M, De Giorgi F, Weber H, Dutta Dubey K, Rovira C, Mattevi A*, Nidetzky B.*
  Deciphering the enzymatic mechanism of sugar ring contraction in UDP-apiose biosynthesis
  Nat Catal, 2, pp. 1115-1123. (2019) - *Shared Corresponding Authors - Cover Image


• Cole PA, Mattevi A.
  Editorial overview: Biological catalysis at the cross-roads of signaling and metabolism
  Curr Opin Struct Biol, S0959-440X, pp. 30107-30101. (2019)


• Buezo Montero S, Gabrieli P, Severini F, Picci L, Di Luca M, Forneris F, Facchinelli L, Ponzi M, Lombardo F, Arcà B.
  Analysis in a murine model points to IgG responses against the 34k2 salivary proteins from Aedes albopictus and Aedes aegypti as novel promising candidate markers of host exposure to Aedes mosquitoes
  PLoS Negl Trop Dis, 13, pp. e0007806. (2019)


• Montefiori M, Pilotto S, Marabelli C, Moroni E, Ferraro M, Serapian SA, Mattevi A*, Colombo G.*
  Impact of mutations on NPAC structural dynamics: mechanistic insights from MD simulations
  J Chem Inf Model, 59, pp. 3927-3937. (2019) - *Shared Corresponding Authors


• Ewans LJ, Colley A, Gaston-Massuet C, Gualtieri A, Cowley MJ, McCabe MJ, Anand D, Lachke S, Scietti L, Forneris F, Zhu Y, Ying K, Walsh C, Kirk EP, Miller D, Giunta C, Sillence D, Dinger M, Buckley M, Roscioli T.
  Pathogenic variants in PLOD3 result in a Stickler syndrome-like connective tissue disorder with vascular complications
  J Med Genet, 56, pp. 629-638. (2019)


• Magnani F*, Mattevi A.*
  Structure and mechanisms of ROS generation by NADPH oxidases
  Curr Opin Struct Biol, 59, pp. 91-97. (2019) - *Shared Corresponding Authors


• Stazi G, Fioravanti R, Mai A, Mattevi A, Valente S.
  Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer
  Curr Opin Chem Biol, 50, pp. 89-100. (2019) - Full-text Download


• Marabelli C*, Marrocco B*, Pilotto S*, Chittori S*, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S**, Mattevi A.**
  A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex
  Cell Rep, 27, pp. 387-399. (2019) - *Equal Contribution - **Shared Corresponding Authors


• Angiolini F, Belloni E, Giordano M, Campioni M, Forneris F, Paola PM, Lupia M, Brandas C, Pradella D, Di Matteo A, Giampietro C, Jodice G, Luise C, Bertalot G, Freddi S, Malinverno M, Irimia M, Moulton JD, Summerton J, Chiapparino A, Ghilardi C, Giavazzi R, Nyqvist D, Gabellini D, Dejana E, Cavallaro U, Ghigna C.
  A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing
  eLife, 8, pp. e44305. (2019)


• Canciani A, Catucci G, Forneris F.
  Structural characterization of the third scavenger receptor cysteine-rich domain of murine Neurotrypsin
  Prot Sci, 28, pp. 746-755. (2019)


• Scietti L*, Campioni M*, Forneris F.
  SiMPLOD, a structure-integrated database of collagen lysyl hydroxylase (LH/PLOD) enzyme variants
  J Bone Min Res, 34, pp. 1372-1386. (2019) - *Equal Contribution - Link to Publication - Explore SiMPLOD


• Loncar N, Fiorentini F, Bailleul G, Savino S, Romero E, Mattevi A, Fraaije MW.
  Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO)
  Appl Microbiol Biotechnol, 103, pp. 1755-1764. (2019)


• Falchetto M*, Ciossani G*, Scolari F, Di Cosimo A, Nenci S, Field LM, Mattevi A, Zhou J-J, Gasperi G**, Forneris F**
  Structural and biochemical evaluation of Ceratitis capitata OBP22 affinity for odorants involved in inter-sex communication
  Ins Mol Biol, 28, pp. 431-443. (2019) - *Equal Contribution - **Shared Corresponding Authors




2018

• Stazi G, Battistelli C, Piano V, Mazzone R, Marrocco B, Marchese S, Louie SM, Zwergel C, Antonini L, Patsilinakos A, Ragno R, Viviano M, Sbardella G, Ciogli A, Fabrizi G, Cirilli R, Strippoli R, Marchetti A, Tripodi M, Nomura DK, Mattevi A, Mai A, Valente S.
  Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
  Eur J Med Chem, 163, pp. 722-735. (2018)


• Fiorentini F, Hatzl AM, Schmidt S, Savino S, Glieder A, Mattevi A
  The extreme structural plasticity in the CYP153 subfamily of P450s directs development of designer hydroxylases
  Biochemistry, 57, pp. 6701-6714. (2018) - Full-text Download


• Furst MJ, Romero E, Gomez-Castellanos JR, Fraaije MW, Mattevi A
  Side-Chain Pruning Has Limited Impact on Substrate Preference in a Promiscuous Enzyme
  ACS Catalysis, 8, pp. 11648-11656. (2018) - Link to Publication


• Oosterheert W, van Bezouwen LS, Rodenburg RNP, Granneman J, Förster F, Mattevi A, Gros P
  Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction
  Nat Commun, 9, pp. 4337. (2018)


• Ceccon M, Millana Fananas E, Massari M, Mattevi A*, Magnani F.*
  Engineering stability in NADPH oxidases: a common strategy for enzyme production
  Mol Membr Biol, 34, pp. 67-76. (2018) - *Shared Corresponding Authors


• Nguyen QT, Romero E, Dijkman W, de Vasconcellos SP, Binda C, Mattevi A, Fraaije MW.
  Structure-based engineering of Phanerochaete chrysosporium alcohol oxidase for enhanced oxidative power towards glycerol
  Biochemistry, 57, pp. 6209-6218. (2018)


• Iacovino LG, Magnani F, Binda C.
  The structure of monoamine oxidases: past, present, and future.
  J Neural Transm, 125, pp. 1567-1579. (2018)


• Scietti L, Chiapparino A, De Giorgi F, Fumagalli M, Khoriauli L, Nergadze S, Basu S, Olieric V, Cucca L, Banushi B, Profumo A, Giulotto E, Gissen P, Forneris F.
  Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
  Nat Commun, 9, pp. 3163. (2018)


• Manzella N, Santin Y, Maggiorani D, Martini H, Douin-Echinard V, Passos JF, Lezoualc'h F, Binda C, Parini A, Mialet-Perez J.
  Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.
  Aging Cell, 17, pp. e12811. (2018)


• Buroni S*, Scoffone VC*, Fumagalli M, Makarov V, Cagnone M, Trespidi G, De Rossi E, Forneris F, Riccardi G, Chiarelli LR.
  Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study
  Front Pharm, 8, pp. 836. (2018) - *Equal Contribution - Link to Publication


• Reis J, Manzella N, Cagide F, Mialet-Perez J, Uriarte E, Parini A, Borges F, Binda C.
  Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis.
  J Med Chem, 61, pp. 4203-4212. (2018)


• Edmondson DE, Binda C.
  Monoamine Oxidases
  Subcell Biochem, 87, pp. 117-139. (2018)


• Pickl M, Swoboda A, Romero E, Winkler C, Binda C, Mattevi A, Faber K, Fraaije M.
  Kinetic Resolution of sec-Thiols via Enantioselective Oxidation with Rationally Engineered 5-(Hydroxymethyl)furfural Oxidase
  Angew Chem Int Ed, 57, pp. 2864-2868. (2018)


• Romero E., Gomez-Castellanos J.R., Gadda G.*, Fraaije M.W.*, Mattevi A.*
  Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes
  Chem Rev, 118, pp. 1742-1769. (2018) - *Shared Corresponding Authors


• Kalin JH**, Wu M**, Gomez AV**, Song Y**, Das, J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Burman SSR, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova A, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR*, Mattevi A*, Alani RM*, Cole PA*
  Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
  Nat Commun, 9, pp. 53. (2018) - **Equal Contribution - *Shared Corresponding Authors




2017

• Fiorentini F, Romero E, Fraaije MW, Faber K, Hall M, Mattevi A.
  Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism.
  ACS Chem Biol, 12, pp. 2379-2387. (2017) -
  


• Speranzini V, Ciossani G, Marabelli C, Mattevi A.
  Probing the interaction of the p53 C-terminal domain to the histone demethylase LSD1
  Arch Biochem Biophys, S0003-9861, pp. 30403-30404. (2017)


• Ewing TA, Nguyen QT, Allan RC, Gygli G, Romero E, Binda C, Fraaije MW, Mattevi A, van Berkel WJH.
  Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl alcohol oxidase.
  J Biol Chem, 292, pp. 14668-14679. (2017)


• Xue X, Wu J, Ricklin D, Forneris F, Di Crescenzio P, Schmidt C, Granneman JC, Sharp TH, Lambris JD, Gros P
  Regulator-dependent mechanisms of C3b processing by factor I allow for differentiation of immune responses
  Nat Struct Mol Biol, 24, pp. 643-651. (2017)


• Montersino S, Te Poele E, Orru R, Westphal AH, Barendregt A, Heck AJR, van der Geize R, Dijkhuizen L, Mattevi A, van Berkel WJH.
  3-Hydroxybenzoate 6-Hydroxylase from Rhodococcus jostii RHA1 Contains a Phosphatidylinositol Cofactor
  Front Microbiol, 16, pp. 1110. (2017)


• Ewing TA, Fraaije MW, Mattevi A, van Berkel WJH.
  The VAO/PCMH flavoprotein family
  Arch Biochem Biophys, S0003-9861, pp. 30360. (2017)


• Magnani F*^#, Nenci S*, Millana Fananas E, Ceccon M, Romero E, Fraaije MW, Mattevi A^#
  Crystal structures and atomic model of NADPH oxidase
  Proc Natl Acad Sci U S A, 114, pp. 6764-6769. (2017) - *Equal Contribution - ^#Shared Corresponding Authors


• Maggiorani D, Manzella N, Edmondson DE, Mattevi A, Parini A, Binda C, Mialet-Perez J.
  Monoamine Oxidases, Oxidative Stress, and Altered Mitochondrial Dynamics in Cardiac Ageing.
  Oxid Med Cell Longev, 2017, pp. 3017947. (2017)


• Tavanti M, Parmeggiani F, Gomes-Castellanos JR, Mattevi A, Turner NJ
  One-pot Biocatalytic Double Oxidation of alpha-Isophorone for the Synthesis of Ketoisophorone
  ChemCatChem, 9, pp. 3338–3348. (2017) - Link to Publication


• Esposito M, Szadocka S, Degiacomi G, Orena BS, Mori G, Piano V, Boldrin F, Zemanova J, Huszár S, Barros D, Ekins S, Lelièvre J, Manganelli R, Mattevi A, Pasca MR, Riccardi G, Ballell L, Mikušová K, Chiarelli LR.
  A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors.
  ACS Infect Dis, 3, pp. 428-437. (2017)


• Kumar H, Nguyen QT, Binda C, Mattevi A, Fraaije MW.
  Isolation and characterization of a thermostable F₄₂₀:NADPH oxidoreductase from Thermobifida fusca.
  J Biol Chem, 292, pp. 10123-10130. (2017)


• De Deurwaerdère P, Binda C, Corne R, Leone C, Valeri A, Valoti M, Ramsay RR, Fall Y, Marco-Contelles J.
  Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine
  ACS Chem Neurosci, 8, pp. 1026-1035. (2017)


• Piano V, Palfey BA, Mattevi A.
  Flavins as Covalent Catalysts: New Mechanisms Emerge.
  Trends Biochem Sci, 42, pp. 457-469. (2017)


• Vetro A, Savasta S, Russo Raucci A, Cerqua C, Sartori G, Limongelli I, Forlino A, Maruelli S, Perucca P, Vergani D, Mazzini G, Mattevi A, Stivala LA, Salviati L, Zuffardi O.
  MCM5: a new actor in the link between DNA replication and Meier-Gorlin syndrome.
  Eur J Hum Genet, 25, pp. 646-650. (2017)


• Vianello P, Sartori L, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Botrugno OA, Villa M, Dessanti P, Minucci S, Vultaggio S, Zagarrí E, Varasi M, Mercurio C.
  Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure Based Drug Design and Structure-Activity Relationship.
  J Med Chem, 60, pp. 1693-1715. (2017)


• Sartori L, Mercurio C, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Vultaggio S, Botrugno OA, Dessanti P, Minucci S, Zagarrí E, Carettoni D, Iuzzolino L, Varasi M, Vianello P.
  Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High Throughput Screening and Preliminary Exploration.
  J Med Chem, 60, pp. 1673-1692. (2017)


• Forneris F*, Mattevi A*
  Expanding the structural biology toolbox with single-molecule holography
  Proc Natl Acad Sci U S A, 114, pp. 1448-1450. (2017)




2016

• Gruber R, Rogerson C, Windpassinger C, Banushi B, Straatman-Iwanowska A, Hanley J, Forneris F, Strohal R, Ulz P, Crumrine D, Menon GK, Blunder S, Schmuth M, Müller T, Smith H, Mills K, Kroisel P, Janecke AR, Gissen P.
  Autosomal recessive Keratoderma-Ichthyosis-Deafness (ARKID) syndrome is caused by VPS33B mutations affecting Rab protein interaction and collagen modification.
  J Invest Dermatol, S0022-202X, pp. 32800-32807. (2016)


• Fürst MJ, Savino S, Dudek HM, Gomez Castellanos JR, Gutiérrez de Souza C, Rovida S, Fraaije MW, Mattevi A.
  Polycyclic Ketone Monooxygenase from the Thermophilic Fungus Thermothelomyces thermophila: A Structurally Distinct Biocatalyst for Bulky Substrates.
  J Am Chem Soc, 139, pp. 627-630. (2016)


• Rusconi F, Grillo B, Toffolo E, Mattevi A, Battaglioli E.
  NeuroLSD1: Splicing-Generated Epigenetic Enhancer of Neuroplasticity.
  Trends Neurosci, 2236, pp. 30164-30163. (2016)


• Nguyen QT, Trinco G, Binda C, Mattevi A, Fraaije MW.
  Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1.
  Appl Microbiol Biotechnol., 10, pp. 2831-2842. (2016)


• Israyilova A, Buroni S, Forneris F, Scoffone VC, Shixaliyev NQ, Riccardi G, Chiarelli LR.
  Biochemical characterization of Glutamate Racemase, a new candidate drug target against Burkholderia cenocepacia infections
  PLoS One, 11, pp. e0167350. (2016)


• Romero E., Gomez-Castellanos J.R., Mattevi A., Fraaije M.W.
  Characterization and Crystal Structure of a Robust Cyclohexanone Monooxygenase
  Angew Chem Int Ed, 55, pp. 15852-15855. (2016)


• Piano V., Nenci S., Magnani F., Aliverti A., Mattevi A.
  Recombinant human dihydroxyacetonephosphate acyl-transferase characterization as an integral monotopic membrane protein
  Biochem Biophys Res Comm, 481, pp. 51-58. (2016)


• Speranzini V., Rotili D., Ciossani G., Pilotto S., Marrocco B., Forgione M., Lucidi A., Forneris F., Mehdipour P., Velankar S., Mai A., Mattevi A.
  Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
  Sci Adv, 2, pp. e1601017. (2016) - Dataset in Repository - Watch the Movie


• Scoffone V.C.*, Chiarelli L.R.*, Makarov V.*, Brackman G., Israylova A., Azzalin A., Forneris F., Riabova O., Savina S., Coenye T., Riccardi G., Buroni S.
  Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo
  Sci Rep, 6, pp. 32487. (2016)


• Palamini M., Canciani A., Forneris F.
  Identifying and visualizing macromolecular flexibility in structural biology
  Front Mol Biosci, 3, pp. 47. (2016)


• Marabelli C., Marrocco B., Mattevi A.
  The growing structural and functional complexity of the LSD1/KDM1A histone demethylase
  Curr Opin Struct Biol, 41, pp. 135-144. (2016)


• Magnani F., Serrano-Vega M.J., Shibata Y., Abdul-Hussein S., Lebon G., Miller-Gallacher J., Singhal A., Strege A., Thomas J.A., Tate C.G.
  A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies
  Nat Prot, 11, pp. 1554-1571. (2016)


• Rotili D., Mattevi A.
  At Long Last Potent and Selective KDM5 Inhibitors
  Cell Chem Biol, 23, pp. 749-751. (2016)


• Banushi B., Forneris F.*, Straatman-Iwanowska A., Strange A., Lyne A., Rogerson C., Burden J.J., Heywood W.E., Hanley J., Doykov I., Straatman K.R., Smith H., Bem D., Kriston-Vizi J., Ariceta G., Risteli M., Wang C., Ardill R.E., Zaniew M., Latka-Grot J., Waddington S.N., Howe S.J., Ferraro F., Gjinovci A., Lawrence S., Marsh M., Girolami M., Bozec L., Mills K., Gissen P.*
  Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
  Nat Commun, 7, pp. 12111. (2016) - *Shared Corresponding Authors


• Spadaro S.*, Scoffone V.C.*, Chiarelli L.R.**, Fumagalli M., Buroni S., Riccardi G., Forneris F.**
  The crystal structure of Burkholderia cenocepacia DfsA provides insights into substrate recognition and quorum sensing fatty acid biosynthesis
  Biochemistry, 55, pp. 3241-3250. (2016) - *Equal Contribution - **Shared Corresponding Authors


• Nguyen Q.T., De Gonzalo G., Binda C., Rioz A., Mattevi A., Fraaije M.W.
  Biocatalytic properties and structural analysis of eugenol oxidase from Rhodococcus jostii RHA1: a versatile oxidative biocatalyst.
  Chembiochem, 17, pp. 1359-1366. (2016)


• Pilotto S.*, Speranzini V.*, Marabelli C., Rusconi F., Toffolo E., Grillo B., Battaglioli E., Mattevi A.
  LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors
  Hum Mol Gen, 25, pp. 2578-2587. (2016) - *Equal Contribution


• Forneris F., Wu J., Xue X., Ricklin D., Lin Z., Sfyroera G., Tzekou A., Volokhina E., Granneman J.C.M., Hauhart R., Bertram P., Liszewski M.K., Atkinson J.P., Lambris J.D., Gros P.
  Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode
  EMBO J, 35, pp. 1133-1149. (2016)


• Savino S., Ferrandi E., Forneris F., Rovida S., Riva S., Monti D., Mattevi A.
  Structural and biochemical insights into 7b-hydroxysteroid dehydrogenase stereoselectivity
  Proteins, 84, pp. 859-865. (2016) - Cover Image


• Speranzini V., Pilotto S., Sixma T.K., Mattevi A.
  Touch, act and go: landing and operating on nucleosomes
  EMBO J, 35, pp. 376-388. (2016)


• Hammuda A., Shalaby R., Rovida S., Edmondson D.E., Binda C., Khalil A.
  Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors.
  Eur J Med Chem, 114, pp. 162-169. (2016)


• Fiorentini F., Geier M., Binda C., Winkler M., Faber K., Hall M., Mattevi A.
  Biocatalytic Characterization of Human FMO5: Unearthing Baeyer-Villiger Reactions in Humans.
  ACS Chem Biol, 11, pp. 1039-1048. (2016)


• Vianello P., Botrugno O.A., Cappa A., Dal Zuffo R., Dessanti P., Mai A., Marrocco B., Mattevi A., Meroni G., Minucci S., Stazi G., Thaler F., Trifiró P., Valente S., Villa M., Varasi M., Mercurio C.
  Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
  J Med Chem, 59, pp. 1501-1517. (2016)




2015

• Piano V., Benjamin D.I., Valente S., Nenci S., Marrocco B., Mai A., Aliverti A., Nomura D.K., Mattevi A.
  Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents.
  ACS Chem Biol, 10, pp. 2589-2597. (2015)


• Mattevi A.
  Dealing with oxygen using bare hands.
  FEBS J, 282, pp. 3259-3261. (2015)


• Dzurova L., Forneris F.*, Savino S., Galuszka P., Vrabka J., Frebort I.*
  The three-dimensional Structure of Lonely Guy from Claviceps purpurea provides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins.
  Proteins, 83, pp. 1539-1546. (2015) - *Shared Corresponding Authors


• Binda C., Robinson R.M., Martin Del Campo J.S., Keul N.D., Rodriguez P.J., Robinson H.H., Mattevi A., Sobrado P.
  An Unprecedented NADPH Domain Conformation in Lysine Monooxygenase NbtG Provides Insights Into Uncoupling of Oxygen Consumption From Substrate Hydroxylation.
  J Biol Chem, 90, pp. 12676-12688. (2015)


• Valente S., Rodriguez V., Mercurio C., Vianello P., Saponara B., Cirilli R., Ciossani G., Labella D., Marrocco B., Monaldi D., Ruoppolo G., Tilset M., Botrugno O.A., Dessanti P., Minucci S., Mattevi A., Varasi M., Mai A.
  Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
  Eur J Med Chem, 94, pp. 163-174. (2015)


• Pilotto S.*, Speranzini V.*, Tortorici M., Durand D., Fish A., Valente S., Forneris F., Mai A., Sixma, T.K., Vachette P., Mattevi A.
  Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation
  Proc Natl Acad Sci U S A, 112, pp. 2752-2757. (2015) - *Equal Contribution - Watch the Movie


• Dijkman W.P., Binda C., Fraaije M.W., Mattevi A.
  Structure-based enzyme tailoring of 5-hydroxymethylfurfural oxidase
  ACS Catalysis, 5, pp. 1833–1839. (2015) - Link to Publication


• Rodriguez V., Valente S.,  Rovida S., Rotili D., Stazi G., Lucidi A., Ciossani G.,  Mattevi A., Botrugno O.A., Dessanti P., Mercurio C., Vianello P.,  Minucci S., Varasi M., Mai A.
  Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells
  Med Chem Commun, 6, pp. 665-670. (2015) - Link to Publication


• Valente S., Rodriguez V., Mercurio C., Vianello P., Saponara B., Cirilli R., Giossani G., Labella D., Marrocco B., Ruoppolo G., Botrugno O.A., Dessanti P., Minucci S., Mattevi A., Varasi M., Mai A.
  Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies
  ACS Med Chem Lett., 6, pp. 173-177. (2015)




2014

• Neres J., Hartkoorn R.C., Chiarelli L.R., Gadupudi R., Pasca M.R., Mori G., Farina D., Savina S., Makarov V., Kolly G.S., Molteni E., Binda C., Dhar N., Ferrari S., Brodin P., Delorme V., Landry V., Ribeiro A.L., Venturelli A., Saxena P., Pojer F., Carta A., Luciani R., Porta A., Zanoni G., De Rossi E., Costi M.P., Riccardi G., Cole S.T.
  2-Carboxyquinoxalines kill Mycobacterium tuberculosis through non-covalent inhibition of DprE1.
  ACS Chem Biol., 10, pp. 705-714. (2014)


• Brondani P.B., Dudek H.M., Martinoli C., Mattevi A., Fraaije M.W.
  Finding the Switch: Turning a Baeyer-Villiger Monooxygenase into a NADPH Oxidase.
  J Am Chem Soc. , 136, pp. 16966-16969. (2014)


• Vianello P., Botrugno O.A., Cappa A., Ciossani G., Dessanti P., Mai A., Mattevi A., Meroni G., Minucci S., Thaler F., Tortorici M., Trifiró P., Valente S., Villa M., Varasi M., Mercurio C.
  Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
  Eur J Med Chem., 86, pp. 352-363. (2014)


• Barrios Á.P., Gómez A.V., Sáez J.E., Ciossani G., Toffolo E., Battaglioli E., Mattevi A., Andrés M.E.
  Differential properties of transcriptional complexes formed by the CoREST family.
  Mol Cell Biol. , 34, pp. 2760-2770. (2014)


• Naik M., Humnabadkar V., Tantry S.J., Panda M., Narayan A., Guptha S., Panduga V., Manjrekar P., Jena L.K., Koushik K., Shanbhag G., Jatheendranath S., Manjunatha M.R., Gorai G., Bathula C., Rudrapatna S., Achar V., Sharma S., Ambady A., Hegde N., Mahadevaswamy J., Kaur P., Sambandamurthy V.K., Awasthy D., Narayan C., Ravishankar S., Madhavapeddi P., Reddy J., Prabhakar K., Saralaya R., Chatterji M., Whiteaker J., McLaughlin B., Chiarelli L.R., Riccardi G., Pasca M.R., Binda C., Neres J., Dhar N., Signorino-Gelo F., McKinney J.D., Ramachandran V., Shandil R., Tommasi R., Iyer P.S., Narayanan S., Hosagrahara V., Kavanagh S., Dinesh N., Ghorpade S.R.
  4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.
  J Med Chem., 57, pp. 5419-5434. (2014)


• Esteban G., Allan J., Samadi A., Mattevi A., Unzeta M., Marco-Contelles J., Binda C., Ramsay R.R.
  Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.
  Biochim Biophys Acta, 1844, pp. 1104-1110. (2014)


• Forneris F., Burnley B.T., Gros P.
  Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D.
  Acta Cryst. D Biol. Cryst., D70, pp. 733-743. (2014)




2013

• Peng W.C., de Lau W., Madoori P.K., Forneris F., Granneman J.C., Clevers H., Gros P.
  Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling.
  PLoS One, 8, pp. e83110-e83110. (2013)


• Rotili D., Tomassi S., Conte M., Benedetti R., Tortorici M., Ciossani G., Valente S., Marrocco B., Labella D., Novellino E., Mattevi A., Altucci L., Tumber A., Yapp C., King O.N., Hopkinson R.J., Kawamura A., Schofield C.J., Mai A.
  Pan-histone demethylase inhibitors simultaneously targeting jumonji C and lysine-specific demethylases display high anticancer activities.
  J Med Chem, 57, pp. 42-55. (2013)


• Martinoli C, Dudek HM, Orru R, Edmondson DE, Fraaije MW, Mattevi A
  Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer–Villiger Oxygenation Reaction.
  ACS Catalysis, 3, pp. 3058-3062. (2013)


• Minde D.P., Radli M., Forneris F., Maurice M.M., Rüdiger S.G.
  Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.
  PLoS One, 8, pp. e77257-e77257. (2013)


• Toffolo E., Rusconi F., Paganini L., Tortorici M., Pilotto S., Heise C., Verpelli C., Tedeschi G., Maffioli E., Sala C., Mattevi A., Battaglioli E.
  Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2.
  J Neurochem, 128, pp. 603-616. (2013)


• Riccardi G., Pasca M.R., Chiarelli L.R., Manina G., Mattevi A., Binda C.
  The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis.
  Appl Microbiol Biotechnol, 97, pp. 8841-8848. (2013)


• Bach R.D., Mattevi A.
  Mechanistic aspects regarding the elimination of H2O2 from C(4a)-hydroperoxyflavin. The role of a proton shuttle required for H2O2 elimination.
  J Org Chem, 78, pp. 8585-8593. (2013)


• Robertson J.C., Hurley N.C., Tortorici M., Ciossani G., Borrello M.T., Vellore N.A., Ganesan A., Mattevi A., Baron R.
  Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin.
  PLoS Comput Biol, 9, pp. e1003158-e1003158. (2013)


• Montersino S., Orru R., Barendregt A., Westphal A.H., van Duijn E., Mattevi A., van Berkel W.J.
  Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation.
  J Biol Chem, 288, pp. 26235-26245. (2013)


• Peng W.C., de Lau W., Forneris F., Granneman J.C., Huch M., Clevers H., Gros P.
  Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.
  Cell Rep, 3, pp. 1885-1892. (2013)


• Tortorici M., Borrello M.T., Tardugno M., Chiarelli L.R., Pilotto S., Ciossani G., Vellore N.A., Bailey S.G., Cowan J., O'Connell M., Crabb S.J., Packham G., Mai A., Baron R., Ganesan A., Mattevi A.
  Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.
  ACS Chem Biol, 8, pp. 1677-1682. (2013)


• Dijkman W.P., de Gonzalo G., Mattevi A., Fraaije M.W.
  Flavoprotein oxidases: classification and applications.
  Appl Microbiol Biotechnol, 97, pp. 5177-5188. (2013)




2012

• Nenci S., Piano V., Rosati S., Aliverti A., Pandini V., Fraaije M.W., Heck A.J., Edmondson D.E., Mattevi A.
  Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis.
  Proc Natl Acad Sci U S A, 109, pp. 18791-18796. (2012) - Watch the Movie


• Neres J., Pojer F., Molteni E., Chiarelli L.R., Dhar N., Boy-Röttger S., Buroni S., Fullam E., Degiacomi G., Lucarelli A.P., Read R.J., Zanoni G., Edmondson D.E., De Rossi E., Pasca M.R., McKinney J.D., Dyson P.J., Riccardi G., Mattevi A., Cole S.T., Binda C.
  Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis.
  Sci Transl Med, 4, pp. 150ra121-150ra121. (2012)


• Franceschini S., Fedkenheuer M., Vogelaar N.J., Robinson H.H., Sobrado P., Mattevi A.
  Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases.
  Biochemistry, 51, pp. 7043-7045. (2012)


• Hadders M.A., Bubeck D., Roversi P., Hakobyan S., Forneris F., Morgan B.P., Pangburn M.K., Llorca O., Lea S.M., Gros P.
  Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.
  Cell Rep, 1, pp. 200-207. (2012)


• Chaiyen P., Fraaije M.W., Mattevi A.
  The enigmatic reaction of flavins with oxygen.
  Trends Biochem Sci, 37, pp. 373-380. (2012)


• Franceschini S., van Beek H.L., Pennetta A., Martinoli C., Fraaije M.W., Mattevi A.
  Exploring the structural basis of substrate preferences in Baeyer-Villiger monooxygenases: insight from steroid monooxygenase.
  J Biol Chem, 287, pp. 22626-22634. (2012)


• Forneris F., Wu J., Gros P.
  The modular serine proteases of the complement cascade.
  Curr Opin Struct Biol, 22, pp. 333-341. (2012)




2011

• Binda C., Aldeco M., Geldenhuys W.J., Tortorici M., Mattevi A., Edmondson D.E.
  Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.
  ACS Med Chem Lett, 3, pp. 39-42. (2011)


• Binda C., Milczek E.M., Bonivento D., Wang J., Mattevi A., Edmondson D.E.
  Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies.
  Curr Top Med Chem, 11, pp. 2788-2796. (2011)


• Milczek E.M., Binda C., Rovida S., Mattevi A., Edmondson D.E.
  The 'gating' residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition.
  FEBS J, 278, pp. 4860-4869. (2011)


• Binda C., Mattevi A., Edmondson D.E.
  Structural properties of human monoamine oxidases A and B.
  Int Rev Neurobiol, 100, pp. 01-nov. (2011)


• Orru R., Dudek H.M., Martinoli C., Torres Pazmiño D.E., Royant A., Weik M., Fraaije M.W., Mattevi A.
  Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization.
  J Biol Chem, 286, pp. 29284-29291. (2011) - Watch the Movie


• Thotsaporn K., Chenprakhon P., Sucharitakul J., Mattevi A., Chaiyen P.
  Stabilization of C4a-hydroperoxyflavin in a two-component flavin-dependent monooxygenase is achieved through interactions at flavin N5 and C4a atoms.
  J Biol Chem, 286, pp. 28170-28180. (2011)


• Kopacz M.M., Rovida S., van Duijn E., Fraaije M.W., Mattevi A.
  Structure-based redesign of cofactor binding in putrescine oxidase.
  Biochemistry, 50, pp. 4209-4217. (2011)


• Baron R., Binda C., Tortorici M., McCammon J.A., Mattevi A.
  Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.
  Structure, 19, pp. 212-220. (2011)


• Binda C., Aldeco M., Mattevi A., Edmondson D.E.
  Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex.
  J Med Chem, 54, pp. 909-912. (2011)




2010

• Forneris F., Ricklin D., Wu J., Tzekou A., Wallace R.S., Lambris J.D., Gros P.
  Structures of C3b in complex with factors B and D give insight into complement convertase formation.
  Science, 330, pp. 1816-1820. (2010)


• Bonivento D., Milczek E.M., McDonald G.R., Binda C., Holt A., Edmondson D.E., Mattevi A.
  Potentiation of ligand binding through cooperative effects in monoamine oxidase B.
  J Biol Chem, 285, pp. 36849-36856. (2010)


• Orru R., Pazmiño D.E., Fraaije M.W., Mattevi A.
  Joint functions of protein residues and NADP(H) in oxygen activation by flavin-containing monooxygenase.
  J Biol Chem, 285, pp. 35021-35028. (2010)


• Rohayem J., Bergmann M., Gebhardt J., Gould E., Tucker P., Mattevi A., Unge T., Hilgenfeld R., Neyts J.
  Antiviral strategies to control calicivirus infections.
  Antiviral Res, 87, pp. 162-178. (2010)


• Binda C., Valente S., Romanenghi M., Pilotto S., Cirilli R., Karytinos A., Ciossani G., Botrugno O.A., Forneris F., Tardugno M., Edmondson D.E., Minucci S., Mattevi A., Mai A.
  Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2.
  J Am Chem Soc, 132, pp. 6827-6833. (2010)


• Zibetti C., Adamo A., Binda C., Forneris F., Toffolo E., Verpelli C., Ginelli E., Mattevi A., Sala C., Battaglioli E.
  Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system.
  J Neurosci, 30, pp. 2521-2532. (2010)


• Bollati M., Alvarez K., Assenberg R., Baronti C., Canard B., Cook S., Coutard B., Decroly E., de Lamballerie X., Gould E.A., Grard G., Grimes J.M., Hilgenfeld R., Jansson A.M., Malet H., Mancini E.J., Mastrangelo E., Mattevi A., Milani M., Moureau G., Neyts J., Owens R.J., Ren J., Selisko B., Speroni S., Steuber H., Stuart D.I., Unge T., Bolognesi M.
  Structure and functionality in flavivirus NS-proteins: perspectives for drug design.
  Antiviral Res, 87, pp. 125-148. (2010)




2009

• Villa F., Capasso P., Tortorici M., Forneris F., de Marco A., Mattevi A., Musacchio A.
  Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization.
  Proc Natl Acad Sci U S A, 106, pp. 20204-20209. (2009)


• Baron R., McCammon J.A., Mattevi A.
  The oxygen-binding vs. oxygen-consuming paradigm in biocatalysis: structural biology and biomolecular simulation.
  Curr Opin Struct Biol, 19, pp. 672-679. (2009)


• Forneris F., Battaglioli E., Mattevi A., Binda C.
  New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin.
  FEBS J, 276, pp. 4304-4312. (2009)


• Baron R., Riley C., Chenprakhon P., Thotsaporn K., Winter R.T., Alfieri A., Forneris F., van Berkel W.J., Chaiyen P., Fraaije M.W., Mattevi A., McCammon J.A.
  Multiple pathways guide oxygen diffusion into flavoenzyme active sites.
  Proc Natl Acad Sci U S A, 106, pp. 10603-10608. (2009)


• Forneris F., Orru R., Bonivento D., Chiarelli L.R., Mattevi A.
  ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding.
  FEBS J, 276, pp. 2833-2840. (2009)


• Karytinos A., Forneris F., Profumo A., Ciossani G., Battaglioli E., Binda C., Mattevi A.
  A novel mammalian flavin-dependent histone demethylase.
  J Biol Chem, 284, pp. 17775-17782. (2009)


• Edmondson D.E., Binda C., Wang J., Upadhyay A.K., Mattevi A.
  Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases.
  Biochemistry, 48, pp. 4220-4230. (2009)


• Speroni S., Rohayem J., Nenci S., Bonivento D., Robel I., Barthel J., Luzhkov V.B., Coutard B., Canard B., Mattevi A.
  Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 A resolution.
  J Mol Biol, 387, pp. 1137-1152. (2009)


• Leferink N.G., Fraaije M.W., Joosten H.J., Schaap P.J., Mattevi A., van Berkel W.J.
  Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases.
  J Biol Chem, 284, pp. 4392-4397. (2009)




2008

• Milczek E.M., Bonivento D., Binda C., Mattevi A., McDonald I.A., Edmondson D.E.
  Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B.
  J Med Chem, 51, pp. 8019-8026. (2008)


• Fraaije M.W., Mattevi A.
  Cyclization in concert.
  Nat Chem Biol, 4, pp. 719-721. (2008)


• Forneris F., Mattevi A.
  Enzymes without borders: mobilizing substrates, delivering products.
  Science, 321, pp. 213-216. (2008)


• Alfieri A., Malito E., Orru R., Fraaije M.W., Mattevi A.
  Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase.
  Proc Natl Acad Sci U S A, 105, pp. 6572-6577. (2008)


• Binda C., Wang J., Li M., Hubalek F., Mattevi A., Edmondson D.E.
  Structural and mechanistic studies of arylalkylhydrazine inhibition of human monoamine oxidases A and B.
  Biochemistry, 47, pp. 5616-5625. (2008)


• Forneris F., Binda C., Battaglioli E., Mattevi A.
  LSD1: oxidative chemistry for multifaceted functions in chromatin regulation.
  Trends Biochem Sci, 33, pp. 181-189. (2008)


• Forneris F., Heuts D.P., Delvecchio M., Rovida S., Fraaije M.W., Mattevi A.
  Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase.
  Biochemistry, 47, pp. 978-985. (2008)


• Coutard B., Gorbalenya A.E., Snijder E.J., Leontovich A.M., Poupon A., De Lamballerie X., Charrel R., Gould E.A., Gunther S., Norder H., Klempa B., Bourhy H., Rohayem J., L'hermite E., Nordlund P., Stuart D.I., Owens R.J., Grimes J.M., Tucker P.A., Bolognesi M., Mattevi A., Coll M., Jones T.A., Aqvist J., Unge T., Hilgenfeld R., Bricogne G., Neyts J., La Colla P., Puerstinger G., Gonzalez J.P., Leroy E., Cambillau C., Romette J.L., Canard B.
  The VIZIER project: preparedness against pathogenic RNA viruses.
  Antiviral Res, 78, pp. 37-46. (2008)


• Speroni S., De Colibus L., Mastrangelo E., Gould E., Coutard B., Forrester N.L., Blanc S., Canard B., Mattevi A.
  Structure and biochemical analysis of Kokobera virus helicase.
  Proteins, 70, pp. 1120-1123. (2008)


• Navazza V., Gabba S., Alfieri A., Giorgetti S., Marchese L., Palladini G., Mattevi A., Ascari E., Caporali R., Montecucco C., Merlini G., Perfetti V.
  Characterization of immunoglobulin variable regions of two human pathogenic monoclonal cryocrystalglobulins.
  Mol Immunol, 45, pp. 1519-1524. (2008)




2007

• Binda C., Wang J., Pisani L., Caccia C., Carotti A., Salvati P., Edmondson D.E., Mattevi A.
  Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.
  J Med Chem, 50, pp. 5848-5852. (2007)


• Razeto A., Mattiroli F., Bossi R., Coda A., Mattevi A.
  Identifying a recombinant alkyldihydroxyacetonephosphate synthase suited for crystallographic studies.
  Protein Expr Purif, 55, pp. 343-351. (2007)


• Edmondson D.E., Binda C., Mattevi A.
  Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B.
  Arch Biochem Biophys, 464, pp. 269-276. (2007)


• Razeto A., Mattiroli F., Carpanelli E., Aliverti A., Pandini V., Coda A., Mattevi A.
  The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder.
  Structure, 15, pp. 683-692. (2007)


• Forneris F., Binda C., Adamo A., Battaglioli E., Mattevi A.
  Structural basis of LSD1-CoREST selectivity in histone H3 recognition.
  J Biol Chem, 282, pp. 20070-20074. (2007)


• Edmondson D.E., DeColibus L., Binda C., Li M., Mattevi A.
  New insights into the structures and functions of human monoamine oxidases A and B.
  J Neural Transm, 114, pp. 703-705. (2007)


• De Colibus L., Speroni S., Coutard B., Forrester N.L., Gould E., Canard B., Mattevi A.
  Purification and crystallization of Kokobera virus helicase.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 63, pp. 193-195. (2007)


• Alfieri A., Fersini F., Ruangchan N., Prongjit M., Chaiyen P., Mattevi A.
  Structure of the monooxygenase component of a two-component flavoprotein monooxygenase.
  Proc Natl Acad Sci U S A, 104, pp. 1177-1182. (2007)




2006

• Forneris F., Rovida S., Heuts D.P., Fraaije M.W., Mattevi A.
  Crystallization and preliminary X-ray analysis of an alditol oxidase from Streptomyces coelicolor A3(2).
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 62, pp. 1298-1300. (2006)


• De Colibus L., Mattevi A.
  New frontiers in structural flavoenzymology.
  Curr Opin Struct Biol, 16, pp. 722-728. (2006)


• Binda C., Hubálek F., Li M., Castagnoli N., Edmondson D.E., Mattevi A.
  Structure of the human mitochondrial monoamine oxidase B: new chemical implications for neuroprotectant drug design.
  Neurology, 67, pp. S5-S7. (2006)


• Forneris F., Binda C., Dall'Aglio A., Fraaije M.W., Battaglioli E., Mattevi A.
  A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1.
  J Biol Chem, 281, pp. 35289-35295. (2006)


• Pennati A., Razeto A., de Rosa M., Pandini V., Vanoni M.A., Mattevi A., Coda A., Aliverti A., Zanetti G.
  Role of the His57-Glu214 ionic couple located in the active site of Mycobacterium tuberculosis FprA.
  Biochemistry, 45, pp. 8712-8720. (2006)


• , Mattevi A.
  A close look at NAD biosynthesis.
  Nat Struct Mol Biol, 13, pp. 563-564. (2006)


• , Mattevi A.
  A monotopic membrane protein goes solo.
  Structure, 14, pp. 628-629. (2006)


• Li M., Binda C., Mattevi A., Edmondson D.E.
  Functional role of the aromatic cage in human monoamine oxidase B: structures and catalytic properties of Tyr435 mutant proteins.
  Biochemistry, 45, pp. 4775-4784. (2006)


• , Mattevi A.
  To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes.
  Trends Biochem Sci, 31, pp. 276-283. (2006)




2005

• Binda C., Hubálek F., Li M., Herzig Y., Sterling J., Edmondson D.E., Mattevi A.
  Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis.
  J Med Chem, 48, pp. 8148-8154. (2005)


• Forneris F., Binda C., Vanoni M.A., Battaglioli E., Mattevi A.
  Human histone demethylase LSD1 reads the histone code.
  J Biol Chem, 280, pp. 41360-41365. (2005)


• De Colibus L., Li M., Binda C., Lustig A., Edmondson D.E., Mattevi A.
  Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B.
  Proc Natl Acad Sci U S A, 102, pp. 12684-12689. (2005)


• Forneris F., Binda C., Vanoni M.A., Mattevi A., Battaglioli E.
  Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process.
  FEBS Lett, 579, pp. 2203-2207. (2005)


• Hubálek F., Binda C., Khalil A., Li M., Mattevi A., Castagnoli N., Edmondson D.E.
  Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.
  J Biol Chem, 280, pp. 15761-15766. (2005)


• Chiarelli L.R., Bianchi P., Fermo E., Galizzi A., Iadarola P., Mattevi A., Zanella A., Valentini G.
  Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia.
  Blood, 105, pp. 3340-3345. (2005)




2004

• Malito E., Alfieri A., Fraaije M.W., Mattevi A.
  Crystal structure of a Baeyer-Villiger monooxygenase.
  Proc Natl Acad Sci U S A, 101, pp. 13157-13162. (2004)


• Malito E., Coda A., Bilyeu K.D., Fraaije M.W., Mattevi A.
  Structures of Michaelis and product complexes of plant cytokinin dehydrogenase: implications for flavoenzyme catalysis.
  J Mol Biol, 341, pp. 1237-1249. (2004)


• Edmondson D.E., Mattevi A., Binda C., Li M., Hubálek F.
  Structure and mechanism of monoamine oxidase.
  Curr Med Chem, 11, pp. 1983-1993. (2004)


• Binda C., Hubálek F., Li M., Edmondson D.E., Mattevi A.
  Crystal structure of human monoamine oxidase B, a drug target enzyme monotopically inserted into the mitochondrial outer membrane.
  FEBS Lett, 564, pp. 225-228. (2004)


• van den H.e., Curti B., Vanoni M.A., Mattevi A.
  Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate.
  Cell Mol Life Sci, 61, pp. 669-681. (2004)


• Binda C., Hubálek F., Li M., Herzig Y., Sterling J., Edmondson D.E., Mattevi A.
  Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class.
  J Med Chem, 47, pp. 1767-1774. (2004)


• Hubálek F., Binda C., Li M., Herzig Y., Sterling J., Youdim M.B., Mattevi A., Edmondson D.E.
  Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.
  J Med Chem, 47, pp. 1760-1766. (2004)


• van den H.e., Westphal A.H., Heck A.J., Walsh M.A., Rovida S., van Berkel W.J., Mattevi A.
  Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action.
  J Biol Chem, 279, pp. 12860-12867. (2004)


• Edmondson D.E., Binda C., Mattevi A.
  The FAD binding sites of human monoamine oxidases A and B.
  Neurotoxicology, 25, pp. 63-72. (2004)




2003

• Hubálek F., Binda C., Li M., Mattevi A., Edmondson D.E.
  Polystyrene microbridges used in sitting-drop crystallization release 1,4-diphenyl-2-butene, a novel inhibitor of human MAO B.
  Acta Crystallogr D Biol Crystallogr, 59, pp. 1874-1876. (2003)


• Binda C., Li M., Hubalek F., Restelli N., Edmondson D.E., Mattevi A.
  Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures.
  Proc Natl Acad Sci U S A, 100, pp. 9750-9755. (2003)


• Terwilliger T.C., Park M.S., Waldo G.S., Berendzen J., Hung L.W., Kim C.Y., Smith C.V., Sacchettini J.C., Bellinzoni M., Bossi R., De Rossi E., Mattevi A., Milano A., Riccardi G., Rizzi M., Roberts M.M., Coker A.R., Fossati G., Mascagni P., Coates A.R., Wood S.P., Goulding C.W., Apostol M.I., Anderson D.H., Gill H.S., Eisenberg D.S., Taneja B., Mande S., Pohl E., Lamzin V., Tucker P., Wilmanns M., Colovos C., Meyer-Klaucke W., Munro A.W., McLean K.J., Marshall K.R., Leys D., Yang J.K., Yoon H.J., Lee B.I., Lee M.G., Kwak J.E., Han B.W., Lee J.Y., Baek S.H., Suh S.W., Komen M.M., Arcus V.L., Baker E.N., Lott J.S., Jacobs W J.r., Alber T., Rupp B.
  The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.
  Tuberculosis (Edinb), 83, pp. 223-249. (2003)


• Di Costanzo L., Forneris F., Geremia S., Randaccio L.
  Phasing protein structures using the group-subgroup relation.
  Acta Crystallogr D Biol Crystallogr, 59, pp. 1435-1439. (2003)


• van den H.e., Svergun D.I., Petoukhov M.V., Coda A., Curti B., Ravasio S., Vanoni M.A., Mattevi A.
  The active conformation of glutamate synthase and its binding to ferredoxin.
  J Mol Biol, 330, pp. 113-128. (2003)




2002

• Bossi R.T., Aliverti A., Raimondi D., Fischer F., Zanetti G., Ferrari D., Tahallah N., Maier C.S., Heck A.J., Rizzi M., Mattevi A.
  A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase.
  Biochemistry, 41, pp. 8807-8818. (2002)


• Ravasio S., Dossena L., Martin-Figueroa E., Florencio F.J., Mattevi A., Morandi P., Curti B., Vanoni M.A.
  Properties of the recombinant ferredoxin-dependent glutamate synthase of Synechocystis PCC6803. Comparison with the Azospirillum brasilense NADPH-dependent enzyme and its isolated alpha subunit.
  Biochemistry, 41, pp. 8120-8133. (2002)


• Binda C., Mattevi A., Edmondson D.E.
  Structure-function relationships in flavoenzyme-dependent amine oxidations: a comparison of polyamine oxidase and monoamine oxidase.
  J Biol Chem, 277, pp. 23973-23976. (2002)


• van den H.e., Ferrari D., Bossi R.T., Ravasio S., Curti B., Vanoni M.A., Florencio F.J., Mattevi A.
  Structural studies on the synchronization of catalytic centers in glutamate synthase.
  J Biol Chem, 277, pp. 24579-24583. (2002)


• Valentini G., Chiarelli L.R., Fortin R., Dolzan M., Galizzi A., Abraham D.J., Wang C., Bianchi P., Zanella A., Mattevi A.
  Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.
  J Biol Chem, 277, pp. 23807-23814. (2002)


• Bossi R.T., Negri A., Tedeschi G., Mattevi A.
  Structure of FAD-bound L-aspartate oxidase: insight into substrate specificity and catalysis.
  Biochemistry, 41, pp. 3018-3024. (2002)


• Binda C., Newton-Vinson P., Hubálek F., Edmondson D.E., Mattevi A.
  Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders.
  Nat Struct Biol, 9, pp. 22-26. (2002)




2001

• Wang C., Chiarelli L.R., Bianchi P., Abraham D.J., Galizzi A., Mattevi A., Zanella A., Valentini G.
  Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia.
  Blood, 98, pp. 3113-3120. (2001)


• Federico R., Leone L., Botta M., Binda C., Angelini R., Venturini G., Ascenzi P.
  Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.
  J Enzyme Inhib, 16, pp. 147-155. (2001)


• Tedeschi G., Ronchi S., Simonic T., Treu C., Mattevi A., Negri A.
  Probing the active site of L-aspartate oxidase by site-directed mutagenesis: role of basic residues in fumarate reduction.
  Biochemistry, 40, pp. 4738-4744. (2001)


• Binda C., Angelini R., Federico R., Ascenzi P., Mattevi A.
  Structural bases for inhibitor binding and catalysis in polyamine oxidase.
  Biochemistry, 40, pp. 2766-2776. (2001)




2000

• Binda C., Bossi R.T., Wakatsuki S., Arzt S., Coda A., Curti B., Vanoni M.A., Mattevi A.
  Cross-talk and ammonia channeling between active centers in the unexpected domain arrangement of glutamate synthase.
  Structure, 8, pp. 1299-1308. (2000)


• Fraaije M.W., van Den H.e., van Berkel W.J., Mattevi A.
  Structural analysis of flavinylation in vanillyl-alcohol oxidase.
  J Biol Chem, 275, pp. 38654-38658. (2000)


• van Den H.e., Fraaije M.W., Ferrer M., Mattevi A., van Berkel W.J.
  Inversion of stereospecificity of vanillyl-alcohol oxidase.
  Proc Natl Acad Sci U S A, 97, pp. 9455-9460. (2000)


• van den H.e., Fraaije M.W., Mattevi A., van Berkel W.J.
  Asp-170 is crucial for the redox properties of vanillyl-alcohol oxidase.
  J Biol Chem, 275, pp. 14799-14808. (2000)


• Valentini G., Chiarelli L., Fortin R., Speranza M.L., Galizzi A., Mattevi A.
  The allosteric regulation of pyruvate kinase.
  J Biol Chem, 275, pp. 18145-18152. (2000)


• Fraaije M.W., Mattevi A.
  Flavoenzymes: diverse catalysts with recurrent features.
  Trends Biochem Sci, 25, pp. 126-132. (2000)




1999

• Fraaije M.W., van den H.e., van Berkel W.J., Mattevi A.
  Covalent flavinylation is essential for efficient redox catalysis in vanillyl-alcohol oxidase.
  J Biol Chem, 274, pp. 35514-35520. (1999)


• Mattevi A., Tedeschi G., Bacchella L., Coda A., Negri A., Ronchi S.
  Structure of L-aspartate oxidase: implications for the succinate dehydrogenase/fumarate reductase oxidoreductase family.
  Structure, 7, pp. 745-756. (1999)


• Binda C., Coda A., Angelini R., Federico R., Ascenzi P., Mattevi A.
  A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase.
  Structure, 7, pp. 265-276. (1999)


• Tedeschi G., Negri A., Ceciliani F., Mattevi A., Ronchi S.
  Structural characterization of l-aspartate oxidase and identification of an interdomain loop by limited proteolysis.
  Eur J Biochem, 260, pp. 896-903. (1999)


• Bacchella L., Lina C., Todone F., Negri A., Tedeschi G., Ronchi S., Mattevi A.
  Crystallization of L-aspartate oxidase, the first enzyme in the bacterial de novo biosynthesis of NAD.
  Acta Crystallogr D Biol Crystallogr, 55, pp. 549-551. (1999)




1998

• Binda C., Coda A., Angelini R., Federico R., Ascenzi P., Mattevi A.
  Crystallization and preliminary X-ray analysis of polyamine oxidase from Zea mays L.
  Acta Crystallogr D Biol Crystallogr, 54, pp. 1429-1431. (1998)


• Binda C., Coda A., Aliverti A., Zanetti G., Mattevi A.
  Structure of the mutant E92K of [2Fe-2S] ferredoxin I from Spinacia oleracea at 1.7 A resolution.
  Acta Crystallogr D Biol Crystallogr, 54, pp. 1353-1358. (1998)


• Fraaije M.W., Van Berkel W.J., Benen J.A., Visser J., Mattevi A.
  A novel oxidoreductase family sharing a conserved FAD-binding domain.
  Trends Biochem Sci, 23, pp. 206-207. (1998)


• , Mattevi A.
  The PHBH fold: not only flavoenzymes.
  Biophys Chem, 70, pp. 217-222. (1998)




1997

• Mattevi A., Vanoni M.A., Curti B.
  Structure of D-amino acid oxidase: new insights from an old enzyme.
  Curr Opin Struct Biol, 7, pp. 804-810. (1997)


• Federico R., Angelini R., Ercolini L., Venturini G., Mattevi A., Ascenzi P.
  Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate.
  Biochem Biophys Res Commun, 240, pp. 150-152. (1997)


• Mattevi A., Fraaije M.W., Mozzarelli A., Olivi L., Coda A., van Berkel W.J.
  Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity.
  Structure, 5, pp. 907-920. (1997)


• Valentini G., Mattevi A., Barilla D., Galizzi A., Speranza M.L.
  Recombinant pyruvate kinase type I from Escherichia coli: overproduction and revised C-terminus of the polypeptide.
  Biol Chem, 378, pp. 719-721. (1997)


• Todone F., Vanoni M.A., Mozzarelli A., Bolognesi M., Coda A., Curti B., Mattevi A.
  Active site plasticity in D-amino acid oxidase: a crystallographic analysis.
  Biochemistry, 36, pp. 5853-5860. (1997)


• Vanoni M.A., Cosma A., Mazzeo D., Mattevi A., Todone F., Curti B.
  Limited proteolysis and X-ray crystallography reveal the origin of substrate specificity and of the rate-limiting product release during oxidation of D-amino acids catalyzed by mammalian D-amino acid oxidase.
  Biochemistry, 36, pp. 5624-5632. (1997)


• Mattevi A., Fraaije M.W., Coda A., van Berkel W.J.
  Crystallization and preliminary X-ray analysis of the flavoenzyme vanillyl-alcohol oxidase from Penicillium simplicissimum.
  Proteins, 27, pp. 601-603. (1997)


• Fraaije M.W., Mattevi A., van Berkel W.J.
  Mercuration of vanillyl-alcohol oxidase from Penicillium simplicissimum generates inactive dimers.
  FEBS Lett, 402, pp. 33-35. (1997)




1996

• Mattevi A., Rizzi M., Bolognesi M.
  New structures of allosteric proteins revealing remarkable conformational changes.
  Curr Opin Struct Biol, 6, pp. 824-829. (1996)


• Rizzi M., Nessi C., Mattevi A., Coda A., Bolognesi M., Galizzi A.
  Crystal structure of NH3-dependent NAD+ synthetase from Bacillus subtilis.
  EMBO J, 15, pp. 5125-5134. (1996)


• Mattevi A., Vanoni M.A., Todone F., Rizzi M., Teplyakov A., Coda A., Bolognesi M., Curti B.
  Crystal structure of D-amino acid oxidase: a case of active site mirror-image convergent evolution with flavocytochrome b2.
  Proc Natl Acad Sci U S A, 93, pp. 7496-7501. (1996)


• Mattevi A., Bolognesi M., Valentini G.
  The allosteric regulation of pyruvate kinase.
  FEBS Lett, 389, pp. 15-19. (1996)




1995

• Mattevi A., Valentini G., Speranza M.L., Sartori P., Bolognesi M., Coda A.
  Crystallization and preliminary X-ray analysis of pyruvate kinase type I from Escherichia coli.
  Acta Crystallogr D Biol Crystallogr, 51, pp. 1089-1091. (1995)


• Mattevi A., Valentini G., Rizzi M., Speranza M.L., Bolognesi M., Coda A.
  Crystal structure of Escherichia coli pyruvate kinase type I: molecular basis of the allosteric transition.
  Structure, 3, pp. 729-741. (1995)


• Hendle J., Mattevi A., Westphal A.H., Spee J., de Kok A., Teplyakov A., Hol W.G.
  Crystallographic and enzymatic investigations on the role of Ser558, His610, and Asn614 in the catalytic mechanism of Azotobacter vinelandii dihydrolipoamide acetyltransferase (E2p).
  Biochemistry, 34, pp. 4287-4298. (1995)




1994

• Schreuder H.A., Mattevi A., Obmolova G., Kalk K.H., Hol W.G., van der B.o., van Berkel W.J.
  Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring.
  Biochemistry, 33, pp. 10161-10170. (1994)




1993

• Conti E., Moser C., Rizzi M., Mattevi A., Lionetti C., Coda A., Ascenzi P., Brunori M., Bolognesi M.
  X-ray crystal structure of ferric Aplysia limacina myoglobin in different liganded states.
  J Mol Biol, 233, pp. 498-508. (1993)


• Mattevi A., Obmolova G., Kalk K.H., van Berkel W.J., Hol W.G.
  Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties.
  J Mol Biol, 230, pp. 1200-1215. (1993)


• Mattevi A., Obmolova G., Kalk K.H., Westphal A.H., de Kok A., Hol W.G.
  Refined crystal structure of the catalytic domain of dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii at 2.6 A resolution.
  J Mol Biol, 230, pp. 1183-1199. (1993)


• Mattevi A., Obmolova G., Kalk K.H., Teplyakov A., Hol W.G.
  Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p).
  Biochemistry, 32, pp. 3887-3901. (1993)




1992

• Mattevi A., Obmolova G., Sokatch J.R., Betzel C., Hol W.G.
  The refined crystal structure of Pseudomonas putida lipoamide dehydrogenase complexed with NAD+ at 2.45 A resolution.
  Proteins, 13, pp. 336-351. (1992)


• Mattevi A., Obmolova G., Schulze E., Kalk K.H., Westphal A.H., de Kok A., Hol W.G.
  Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex.
  Science, 255, pp. 1544-1550. (1992)




1991

• Schulze E., Westphal A.H., Obmolova G., Mattevi A., Hol W.G., de Kok A.
  The catalytic domain of the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii and Escherichia coli. Expression, purification, properties and preliminary X-ray analysis.
  Eur J Biochem, 201, pp. 561-568. (1991)


• Mattevi A., Schierbeek A.J., Hol W.G.
  Refined crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii at 2.2 A resolution. A comparison with the structure of glutathione reductase.
  J Mol Biol, 220, pp. 975-994. (1991)


• Mattevi A., Gatti G., Coda A., Rizzi M., Ascenzi P., Brunori M., Bolognesi M.
  Binding mode of azide to ferric Aplysia limacina myoglobin. Crystallographic analysis at 1.9 A resolution.
  J Mol Recognit, 4, pp. 01-giu. (1991)




1990

• Eschrich K., van Berkel W.J., Westphal A.H., de Kok A., Mattevi A., Obmolova G., Kalk K.H., Hol W.G.
  Engineering of microheterogeneity-resistant p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.
  FEBS Lett, 277, pp. 197-199. (1990)

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