The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is complemented by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes enzymes of the neurotransmitter metabolism, protein complexes involved in chromatin remodeling, enzymatic systems for the biosynthesis of a class of membrane phospholipids, large macromolecular complexes involved in synapse formation and stabilization, and the reactivity of flavoenzymes with oxygen.
04/01/2018 - New Publication
New Nature Communications paper, describing development and usage of dual histone deacetylase and demethylase inhibitors to target the LSD1-CoREST-HDAC complex. Browse the publications of our groups.
13/09/2017 - EMBO Workshop
We are pleased to announce the EMBO workshop Enzymes, biocatalysis and chemical biology: The new frontiers, which will take place in Pavia, 09–12 September 2018.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)