The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is complemented by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes enzymes of the neurotransmitter metabolism, protein complexes involved in chromatin remodeling, enzymatic systems for the biosynthesis of a class of membrane phospholipids, large macromolecular complexes involved in synapse formation and stabilization, and the reactivity of flavoenzymes with oxygen.





Latest News:

13/09/2017 - EMBO Workshop
We are pleased to announce the EMBO workshop Enzymes, biocatalysis and chemical biology: The new frontiers, which will take place in Pavia, 0912 September 2018.


03/09/2017 - New Publication
New ACS Chem Biol paper, describing implications of FMO5 in drug metabolism. Browse the publications of our groups. This article has received a recommendation from the Faculty of 1000.
Access the recommendation on F1000Prime




Structural Biology @ UniPV
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)



        Our work is funded by:

The Armenise-Harvard Foundation    Epigen - Epigenomics Flagship Project    Italian Association for Cancer Research (AIRC)    Fondazione Cariplo    Austian Centre for Industrial Biotechnology    ROBOX - Expanding the Industrial Use of Robust Oxidative Biocatalysts for the Conversion and Production of Alcohols - An H2020 Project     OXYTRAIN is a EU-H2020 Training Program focusing on characterization of four major classes of oxygenases    Marie Curie Actions - H2020 Individual Postdoctoral Fellowships