The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is complemented by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes enzymes of the neurotransmitter metabolism, protein complexes involved in chromatin remodeling, enzymatic systems for the biosynthesis of a class of membrane phospholipids, large macromolecular complexes involved in synapse formation and stabilization, and the reactivity of flavoenzymes with oxygen.

Latest News:

13/01/2018 - New Publication
New publication in Chemical Reviews, describing the variety of mechanisms adopted by flavoenzymes to activate molecular oxygen. Browse the publications of our groups.

04/01/2018 - New Publication
New Nature Communications paper, describing development and usage of dual histone deacetylase and demethylase inhibitors to target the LSD1-CoREST-HDAC complex. Browse the publications of our groups.

13/09/2017 - EMBO Workshop
We are pleased to announce the EMBO workshop Enzymes, biocatalysis and chemical biology: The new frontiers, which will take place in Pavia, 0912 September 2018.

Structural Biology @ UniPV
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)

        Our work is funded by:

The Armenise-Harvard Foundation    Epigen - Epigenomics Flagship Project    Italian Association for Cancer Research (AIRC)    Fondazione Cariplo    Austian Centre for Industrial Biotechnology    ROBOX - Expanding the Industrial Use of Robust Oxidative Biocatalysts for the Conversion and Production of Alcohols - An H2020 Project     OXYTRAIN is a EU-H2020 Training Program focusing on characterization of four major classes of oxygenases    Marie Curie Actions - H2020 Individual Postdoctoral Fellowships