The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is complemented by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes enzymes of the neurotransmitter metabolism, protein complexes involved in chromatin remodeling, enzymatic systems for the biosynthesis of a class of membrane phospholipids, large macromolecular complexes involved in synapse formation and stabilization, and the reactivity of flavoenzymes with oxygen.

Latest News:

08/06/2017 - New Publication
New PNAS paper, describing the crystal structure of bacterial NOX5 fragments and implications of ROS production in various biological processes. Browse the publications of our groups.

08/06/2017 - New Publication
New ChemCatChem paper, describing new biocatalytic reactions for chemical synthesis of ketoisophorone, a result achieved through the ROBOX network. Browse the publications of our groups.

16/02/2017 - Cryo-EM School
We are pleased to announce the 2017 edition of the Italian Association for Crystallography (AIC) International Crystallography School (AICS2017). This year's school title will be "Bridging the gap between cryo-EM and crystallography". The school will be held in Pavia, Italy, from 3 to 6 September 2017.

14/02/2017 - PhD Position
Our group is part of the OXYTRAIN Marie Curie PhD Program, and positions are available!

Structural Biology @ UniPV
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)

        Our work is funded by:

The Armenise-Harvard Foundation    Epigen - Epigenomics Flagship Project    Italian Association for Cancer Research (AIRC)    Fondazione Cariplo    Austian Centre for Industrial Biotechnology    ROBOX - Expanding the Industrial Use of Robust Oxidative Biocatalysts for the Conversion and Production of Alcohols - An H2020 Project     OXYTRAIN is a EU-H2020 Training Program focusing on characterization of four major classes of oxygenases    Marie Curie Actions - H2020 Individual Postdoctoral Fellowships