The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is complemented by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes enzymes of the neurotransmitter metabolism, protein complexes involved in chromatin remodeling, enzymatic systems for the biosynthesis of a class of membrane phospholipids, large macromolecular complexes involved in synapse formation and stabilization, and the reactivity of flavoenzymes with oxygen.
17/10/2016 - Seminar
On Friday October 21st, at 2:30 PM (Aula Buzzati-Traverso), we will host the seminar of Dr. Fabrizio Martino (CIB Madrid), titled "High-resolution structure investigation of protein complexes bound to the nucleosome core particle".
09/09/2016 - New Publication
New Science Advances paper describing two new classes of non-covalent LSD1 inhibitors with highly unusual structural features. Watch the Movie related to our paper - Browse the publications of our groups.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)