The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is complemented by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes enzymes of the neurotransmitter metabolism, protein complexes involved in chromatin remodeling, enzymatic systems for the biosynthesis of a class of membrane phospholipids, large macromolecular complexes involved in synapse formation and stabilization, and the reactivity of flavoenzymes with oxygen.





Latest News:

30/07/2016 - New Publication
New Current Opinions in Structural Biology review describing the structural and functional complexity of histone demethylase LSD1. Browse the publications of our groups.


29/07/2016 - New Publication
New Nature Protocols paper describing protocols and advice are given on how to develop thermostability assays for membrane proteins and how to combine mutations to make an optimally stable mutant suitable for structural studies. Browse the publications of our groups.


20/07/2016 - New Publication
New Nature Communications paper describing the discovery of a new post-Golgi trafficking pathway for the enzyme LH3/PLOD3 critical for collagen homeostasis. Browse the publications of our groups.




Structural Biology @ UniPV
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)



        Our work is funded by:

The Armenise-Harvard Foundation    Epigen - Epigenomics Flagship Project    Italian Association for Cancer Research (AIRC)    Fondazione Cariplo    Austian Centre for Industrial Biotechnology    ROBOX - Expanding the Industrial Use of Robust Oxidative Biocatalysts for the Conversion and Production of Alcohols - An H2020 Project