The common theme of the research projects in our groups is the investigation of medically relevant proteins and enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is complemented by other approaches such as biochemistry, biophysics, cell biology and computational chemistry. Current research includes enzymes of the neurotransmitter metabolism, protein complexes involved in chromatin remodeling, enzymatic systems for the biosynthesis of a class of membrane phospholipids, large macromolecular complexes involved in synapse formation and stabilization, and the reactivity of flavoenzymes with oxygen.
12/02/2019 - New Publication
New publication in Protein Science, describing the crystal structure and the biochemical characterization of the third SRCR domain of murine Neurotrypsin. Browse the publications of our groups.
05/02/2019 - SiMPLOD
A structure-integrated curated online database of PLOD mutations, from Federico's group, is now online at http://fornerislab.unipv.it/SiMPLOD. An accompanying publication in The Journal of Bone and Mineral Research, describes the idea behing the database and its functionality. Browse the publications of our groups.
Department of Biology and Biotechnology "L. Spallanzani"
University of Pavia
Via Ferrata, 9
I-27100 PAVIA (Italy)